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Patient Eligibility Criteria

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Consider Optune Lua for mNSCLC at first signs of progression on or after a platinum-based regimen1

Optune Lua is a noninvasive wearable device approved for use with PD-1/PD-L1 inhibitors or docetaxel following progression on or after a platinum-based regimen1

  • Progression can occur at any point after starting a platinum-based regimen, regardless of being on maintenance treatment1

Optune Lua may help expand your patients’ treatment strategies with PD-1/PD-L1 inhibitors or docetaxel1

Key Clinical Characteristics from LUNAR1

  • Stage: IV
  • Disease progression on or after a platinum-based regimen, regardless of being on maintenance treatment
  • ECOG: 0-2
  • Adult patients (22 years or older)
  • Not pregnant, trying to get pregnant, might be pregnant, or breastfeeding
  • Does not have a known sensitivity to gel used with Optune Lua
  • Progression on or after platinum-based chemotherapy
  • No implantable electronic medical devices in the upper torso (eg, pacemaker) or active CNS metastases 

Based on the broad study population, Optune Lua may be appropriate regardless of:

  • Histology
  • PD-L1 status2
  • Driver mutations
  • Smoking status
  • Site of metastases

Patient Motivation and Goals   

  • Patients who want more control over their therapy (ie, want to be active participants)   
  • Seeking a noninvasive option that can be used with either chemotherapy or IO
  • Patients who are motivated to extend survival 

Optune Lua is the first and only FDA-approved wearable treatment for use with a PD-1/PD-L1 inhibitor or docetaxel in mNSCLC following progression on or after a platinum-based regimen1

David

55 years old

Patient had durable response to IO + platinum doublet, now with slow progression during maintenance IO 

See patient profiles for Optune Lua
IMG

ECOG, Eastern Cooperative Oncology Group; IO, immuno-oncology; mNSCLC, metastatic non–small cell lung cancer; PD-1/PD-L1,   programmed cell death 1 protein/programmed cell death 1 ligand 1.

 

References: 1. Optune Lua for Non-Small Cell Lung Cancer (NSCLC). Physician Instructions for Use. Novocure; 2024. 2. Novocure Data on File GLB-DOF-0020.

Important Safety Information 

Contraindications 

Do not use Optune Lua® in patients with an electrical implant. Use of Optune Lua together with electrical implants has not been tested and may lead to malfunctioning of the implanted device. 

 

Do not use Optune Lua in patients known to be sensitive to conductive hydrogels. In this case, skin contact with the gel used with Optune Lua may commonly cause increased redness and itching, and rarely may even lead to severe allergic reactions, such as a fall in blood pressure and breathing difficulty.

Warnings and Precautions 

Optune Lua can only be prescribed by a healthcare provider that has completed the required certification training provided by Novocure® (the device manufacturer). 

 

Do not prescribe Optune Lua for patients who are pregnant, whom you think might be pregnant, or who are trying to get pregnant, as the safety and effectiveness of Optune Lua in these populations have not been established. 

 

The most common (≥10%) adverse events involving Optune Lua concurrent with PD-1/PD-L1 inhibitors or docetaxel were dermatitis, musculoskeletal pain, fatigue, anemia, dyspnea, nausea, cough, diarrhea, anorexia, pruritus, leukopenia, pneumonia, respiratory tract infection, localized edema, rash, pain, constipation, skin ulcers, and hypokalemia. 

 

Other potential adverse effects associated with the use of Optune Lua include treatment related skin toxicity, allergic reaction to the adhesive or to the gel, overheating of the array leading to pain and/or local skin burns, infections at the site where the arrays make contact with the skin, local warmth and tingling sensation beneath the arrays, medical device site reaction, muscle twitching, and skin breakdown or skin ulcer. 

 

If the patient has an underlying serious skin condition on the chest, evaluate whether this may prevent or temporarily interfere with Optune Lua treatment.

 

Indication For Use

Optune Lua is intended as a treatment concurrent with PD-1/PD-L1 inhibitors or docetaxel for adult patients with metastatic non-small cell lung cancer who have progressed on or after a platinum-based regimen. 

 


Please see full Instructions For Use (IFU) and Patient Information and Operation Manual (PIOM) for Optune Lua®.

Important Safety Information 

Contraindications 

Do not use Optune Lua® in patients with an electrical implant. Use of Optune Lua together with electrical implants has not been tested and may lead to malfunctioning of the implanted device. 

 

Do not use Optune Lua in patients known to be sensitive to conductive hydrogels. In this case, skin contact with the gel used with Optune Lua may commonly cause increased redness and itching, and rarely may even lead to severe allergic reactions, such as a fall in blood pressure and breathing difficulty.

Warnings and Precautions 

Optune Lua can only be prescribed by a healthcare provider that has completed the required certification training provided by Novocure® (the device manufacturer). 

 

Do not prescribe Optune Lua for patients who are pregnant, whom you think might be pregnant, or who are trying to get pregnant, as the safety and effectiveness of Optune Lua in these populations have not been established. 

 

The most common (≥10%) adverse events involving Optune Lua concurrent with PD-1/PD-L1 inhibitors or docetaxel were dermatitis, musculoskeletal pain, fatigue, anemia, dyspnea, nausea, cough, diarrhea, anorexia, pruritus, leukopenia, pneumonia, respiratory tract infection, localized edema, rash, pain, constipation, skin ulcers, and hypokalemia. 

 

Other potential adverse effects associated with the use of Optune Lua include treatment related skin toxicity, allergic reaction to the adhesive or to the gel, overheating of the array leading to pain and/or local skin burns, infections at the site where the arrays make contact with the skin, local warmth and tingling sensation beneath the arrays, medical device site reaction, muscle twitching, and skin breakdown or skin ulcer. 

 

If the patient has an underlying serious skin condition on the chest, evaluate whether this may prevent or temporarily interfere with Optune Lua treatment.

 

Indication For Use

Optune Lua is intended as a treatment concurrent with PD-1/PD-L1 inhibitors or docetaxel for adult patients with metastatic non-small cell lung cancer who have progressed on or after a platinum-based regimen. 

 


Please see full Instructions For Use (IFU) and Patient Information and Operation Manual (PIOM) for Optune Lua®.

Novocure Websites

This website is intended for US healthcare professionals seeking information on Optune Lua.

 

 

 

 

External links

OptuneGioHCP.com
OptuneLuaHCP.com/MPM
Novocuretrials.com

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US-OPL-00070 v3.0 July 2025